09:15 – 10:00 - Kappers Lecture (AM 1)

10:00 – 10:30 - Coffee Break

SYMPOSIUM 1: CLOCKS IN THE BRAIN
10:30 – 12:30 (AM 1)

SYMPOSIUM 2: METABOLISM
10:30 – 12:30 (AM 2)

SYMPOSIUM 3: BIOLOGICAL TIMING FRONTIERS IN PSYCHIATRIC DISORDERS & MENTAL HEALTH
10:30 – 12:30 (AM 3)

SYMPOSIUM 4: SHORT AND LONG CLOCKS
10:30 – 12:30 (AM 4)

12:30 – 12:40 - Group Photo of All Participants (Entrance Stairs)

12:40 – 14:00 - Lunch Break and Poster Session A

09:15 – 10:00 - Kappers Lecture (AM 1)

10:00 – 10:30 - Coffee Break

Symposium 1: CLOCKS IN THE BRAIN

10:30 – 12:30 (AM 1)
10:30 - Suprachiasmatic circadian circuits 10:55 - The SCN neuronal network in diurnal animals 11:20 - Visualization of cellular and network rhythmicity in the suprachiasmatic nucleus in vivo 11:45 - How clocks talk to clocks globally 12:10 - Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

Symposium 2: METABOLISM

10:30 – 12:30 (AM 2)
10:30 - Rhythms in the gut - a novel link between diet and metabolism? 10:55 - From circadian clock resetting to hepatopulmonary syndrome 11:20 - Human meal anticipation 11:45 - A sexually dimorphic hepatic cycle of periportal VLDL generation and subsequent pericentral VLDLR-mediated re-uptake 12:00 - Protein Secretion Ex Vivo Reveals Regulation of Hepatokines by the Liver Circadian Clock 12:15 - Re-scoping ultradian metabolism

Symposium 3: BIOLOGICAL TIMING FRONTIERS IN PSYCHIATRIC DISORDERS & MENTAL HEALTH

10:30 – 12:30 (AM 3)
10:30 - The light-dark cycle during development and later life affective disorders 10:55 - New approaches to studying mechanisms underlying sleep and circadian rhythm disruption in mental health 11:20 - Delayed sleep timing and mental disorder: implications and interventions 11:45 - Relaxation of social time pressure extends fasting and reveals a tight coupling between sleep/wake and fast/eat daily behaviors 12:00 - Evening light reduction for improving depressive and insomnia symptoms in people taking an SSRI 12:15 - Impact of night shifts on cognitive, psychological, and cardiovascular health: findings from the OPTI-SHIFT observational study

Symposium 4: SHORT AND LONG CLOCKS

10:30 – 12:30 (AM 4)
10:30 - Lunar effects on the behavior of humans and other primates 10:55 - Photoperiodism: insights from insects 11:20 - Timing in the deep sea: circatidal rhythms in a hot vent shrimp 11:45 - Faster clock in mice and cells lacking mRNA cap methylation 12:00 - Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body 12:15 - Platynereis dumerilii as a functional molecular model organism for circalunar clock analyses
12:30 – 12:40 - Group Photo of All Participants (Entrance Stairs)
12:40 – 14:00 - Lunch Break and Poster Session A

Symposium 5: CELL BIOLOGY

14:00 – 16:00 (AM 3)
14:00 - Allele-Specific Expression in Circadian Clock Genes Across Multiple Tissues in Baboons 14:25 - Investigating the mechanisms driving TRE-induced fat loss 14:50 - Talk 15:15 - Linking the establishment of circadian rhythm with the establishment of long-term epigenetic silencing 15:40 - Role of GRIP1 as a Coactivator in Bmal1 Promoter Rhythm Formation

Symposium 6: CLOCK, BRAIN AND BEHAVIOR

14:00 – 16:00 (AM 1)
14:00 - A Mechanism for Circadian Rest Time Allocation 14:25 - Clock in the choroid plexus is a gatekeeper for the brain 14:50 - On the role of circadian dopamine rhythms in mammalian time memory 15:15 - Elucidating The Mechanisms of Bright Light Therapy via Per1 15:30 - Identification of the key diffusible output factor that regulates circadian behavioral rhythms 15:45 - Light intensity modulates thermoregulation in a cooling environment

Symposium 7: CIRCADIAN MEDICINE: DETECTING THE CLOCK

14:00 – 16:00 (AM 2)
14:00 - Circadian clock detection in humans: challenges and opportunities 14:25 - Decoding circadian clock state heterogeneity at single-cell resolution 14:50 - Temporal patterns in circadian alignment: insights from real-life behavioral data 15:15 - Telling time from intercellular communication in the blood-brain barrier 15:30 - Quantifying Circadian Rhythmicity in Vital Signs of Preterm Infants in the NICU: A Cosinor-Based Approach 15:45 - Little overlap in circadian phase biomarker predictors developed from different methods/datasets, but overlap in underlying biological processes

Symposium 8: EVOLUTION

14:00 – 16:00 (AM 4)
14:00 - Evolution of circadian clock genes 14:25 - Mechanisms underlying circadian plasticity loss in an equatorial endemic species 14:50 - Punctual parasites: why are rhythms advantageous? 15:15 - Circadian and ultradian membrane potential rhythms in hawkmoth olfactory receptor neurons depend on Orco, indicative of an endogenous multiscale membrane clockwork 15:30 - Towards a molecular understanding of moon-controlled timers: Linking the light valence detector L-Cry to the circalunar clock in the marine annelid Platynereis dumerilii 15:45 - Cryptochrome and magnetic fields in Drosophila
16:00 – 16:30 - Coffee Break

Symposium 9: PRESIDENT’S SYMPOSIUM

16:30 – 18:15 (AM 1)
16:30 – 16:35 - Introduction by Chair
16:35 - Circadian anti-tumor immune responses 17:00 - Who, when, where: tissue-specificity in the plant circadian system 17:25 - Asthma… it’s about time! 17:50 - What drives daily rhythms in physiology?
Evening Activity – TBD

08:15 – 09:00 - EBRS Board Meeting (by invitation only) (AM S2)


09:15 – 10:00 - Axelrod Lecture (AM 1)
(part of Leopoldina Symposium)

10:00 – 10:30 - Coffee Break

Symposium 10: ESRS-EBRS JOINT SYMPOSIUM

(part of Leopoldina Symposium)
10:30 – 12:30 (AM 1)
10:30 - Sleep & Rhythm in Neurodegeneration 10:55 - Effects of photoperiod in development and adulthood on sleep 11:20 - Sleep is for brain cleaning – mechanisms and function of the glymphatic system 11:45 - Stimulating waves – Sleep and memory consolidation 12:10 - Impacts of Night Work and Seasonal Variation on Wearable-Derived Sleep Architecture in Arctic Industrial Workers

Symposium 11: ENDOCRINE FUNCTION

10:30 – 12:30 (AM 2)
10:30 - Is there an optimal time of the day to exercise? 10:55 - Control of hepatic transcriptional and metabolic rhythms by glucocorticoid hormones 11:20 - Restoring 24-hour substrate rhythmicity to improve glycemic control by timing of lifestyle factors 11:45 - Cellular Clocks on Steroids: How Glucocorticoids Signal Time of Day to Circadian Clocks 12:00 - Night work affects diurnal rhythms of cortisol, melatonin, and testosterone in permanent night workers 12:15 - Diurnal Variation in Human Plasma Metabolites and Circadian Hormones Across Seasons

Symposium 12: CIRCADIAN MEDICINE: TARGETING THE CLOCK

10:30 – 12:30 (AM 3)
10:30 - Emerging links between the sleep and circadian system and cardiometabolic disease 10:55 - The Potential of Circadian Medicine to Prevent Delirium in the ICU and Post-Intensive Care Syndrome 11:20 - Minding the Implementation Gap in Circadian Medicine: Lessons from ADHD 11:45 - Impact of early vs. late time-restricted eating on glucose and lipid profiles and internal circadian time in overweight or obese women 12:00 - Clocking the clot: A novel use for a circadian clock compound to restore clot breakdown pathways inhibited by inflammation 12:15 - Targeting BMAL1 to develop various circadian medicines

Symposium 13: CLOCKS IN THE WILD

10:30 – 12:30 (AM 4)
10:30 - The circadian clock in the deep sea 10:55 - Effects of environmental factors on rhythms in mosquito-host interactions 11:20 - Ultradian sleep cycle dynamics during human infancy 11:45 - Light pollution alters immune rhythmicity and function in nocturnal and diurnal wild rodents 12:00 - Weak coupling between energetic status and timing of seasonal reproduction in an Arctic ungulate 12:15 - Entrainment in natural conditions
12:30 – 14:00 - Lunch Break and Poster Session B

Symposium 14: POST-TRANSLATIONAL REGULATIONS IN CLOCK AND SLEEP (JSC-EBRS JOINT SYMPOSIUM)

(part of Leopoldina Symposium)
14:00 – 16:10 (AM 1)
14:00 - Mouse Circadian Proteome Atlas and Post-translational Regulations in the Circadian Clock 14:25 - Towards Human Systems Biology of Sleep/Wake Cycles: The Role of Calcium and Phosphorylation in Sleep 14:50 - Beyond Timekeeping: Roles of Post-Translational Modifications of Clock Proteins 15:15 - Digital twins for circadian-sleep health? 15:30 - Perinatal photoperiod has lasting effects on the sleep-wake cycle and the circadian system 15:45 - Influence of Circadian Phenotypes on Excessive Sleepiness, Sleep Disturbance and Performance in Patients with Shift-Work Disorder

Symposium 15: MOLECULAR SLEEP CIRCUITS

14:00 – 16:00 (AM 4)
14:00 - Cortical Interneurons Convey Infraslow Oscillations During Sleep 14:20 - Sleep deprivation enhances decision making in larval zebrafish 14:40 - Network synchrony creates neural filters promoting quiescence in Drosophila 15:00 - Sleep - A Worm's-Eye View 15:15 - Lovit protein in photoreceptors regulates histamine-mediated Drosophila sleep 15:30 - Genetic basis of the natural polymorphisms of sleep-wake rhythms in Drosophila 15:45 - VIP and its receptor (VPAC2R) in circadian timing of the sleep-wake cycles

Symposium 16: METABOLIC DISORDERS

14:00 – 16:00 (AM 3)
14:00 - Neuronal circadian circuit controlling metabolism during sleep revealed by an engineered transcriptional switch 14:25 - Defining the islet cell-specific binding landscape of core-clock protein Bmal1 14:50 - The circadian control of energy metabolism: implications for people with obesity, type 2 diabetes, and shift workers 15:15 - Effect of chronodisruption on gut circadian clock rhythmicity in human intestinal organoids 15:30 - The impact of misalignment with the external light cycle on diabetic retinopathy 15:45 - Tert deletion impairs circadian regulation of blood pressure in spontaneously hypertensive rats

Symposium 17: NEURAL CIRCUITS CONTROLLING CIRCADIAN TIMEKEEPING

14:00 – 16:00 (AM 2)
14:00 - Glial control of circadian rhythms 14:25 - Dissecting the Neural Network of Mammalian Circadian Clock 14:50 - The role of oligodendroglia in sleep and circadian rhythms 15:15 - GABA transmission in AVP neurons of the SCN is essential for regular estrous cycling in mice 15:30 - Integrity of the circadian clock determines regularity of high-frequency and diurnal LFP rhythms within and between brain areas 15:45 - Role of Ca2+ signaling for Oscillation of Circadian Transcriptional Circuits
16:00 – 16:30 - Coffee Break

16:30 – 17:00 - Discussion on Statements (AM 2)

17:15 – 18:00 - JSC Lecture (AM 1)
(part of Leopoldina Symposium)

18:15 – 19:00 – Leopoldina Public Lecture (AM 1)
(part of Leopoldina Symposium)

Evening Activity - TBD

09:15 – 10:00 - Gwinner Lecture (AM 1)

10:00 – 10:30 - Coffee Break

Symposium 18: SYSTEMS CHRONOBIOLOGY

10:30 – 12:30 (AM 2)
10:30 - Hair test reveals plasticity of human chronotype 10:55 - Human genetics of the clock and light sensitivity 11:20 - Systemwide transcriptome and behavioral plasticity as an adaptation strategy to changing energy demand 11:45 - The balancing act of the SCN 12:10 - A systems biology approach to analyze intercellular coupling of peripheral circadian clocks

Symposium 19: WHEREFORE A TTFL?

10:30 – 12:30 (AM 1)
10:30 - Preparation for food availability, and other important things 10:55 - A dopamine regulated circadian resonator underlying sensorimotor integration 11:20 - The post-translational nature of mammalian circadian timekeeping 11:45 - The chronology of developing cells: epigenomic and transcriptomic oscillations are interlinked with linear trajectories 12:10 - A functional analysis of circadian pacemakers in mPers-deficient mice

Symposium 20: CIRCADIAN MEDICINE IN PATIENT CARE

10:30 – 12:30 (AM 4)
10:30 - Light, circadian rhythms, and psychiatry 10:55 - Sampling in the real world: What can ambulatory biosampling tell us about our rhythms? 11:20 - Circadian Medicine in the Intensive Care Unit 11:45 - Can translational studies help to determine the optimal time point for cancer therapy in humans? 12:00 - Effect of cyclic daytime versus continuous enteral nutrition on circadian rhythms in patients in the Intensive Care Unit: a randomized controlled trial 12:15 - Preliminary Results of a Scoping Review of use of Wearables and Internet of Things Technologies in Circadian Medicine

Symposium 21: CLOCKS IN DIVERSE SPECIES

10:30 – 12:30 (AM 3)
10:30 - Interplay of Circadian Clocks, DNA Damage, and Sleep Patterns in Cnidarians with Divergent Chronotypes 10:55 - The sexy clock of the bee: The influence of sex and caste on circadian rhythms 11:20 - Clocks in the dark: Adaptations of circadian clocks in cave animals 11:45 - Low-Temperature Dynamics in Single Cyanobacterial Cells Highlight Critical Features of Circadian Clock Response 12:00 - How beetles tick- Insights into the circadian system of the model species Tribolium castaneum 12:15 - The membrane hand of the circadian clock in flies and mice: Experimental and modelling insights
12:30 – 14:00 - EBRS Members’ Assembly (AM 1)

14:00 – 19:00 - Free Time or Social Activities

19:00 - Banquet in Schuppen 9

09:15 – 10:00 - Keynote Lecture (AM 1)

10:00 – 10:30 - Coffee Break

Symposium 22: COMPUTATION AND MODELING

10:30 – 12:30 (AM 4)
10:30 - Mathematical modeling and controlling of spatiotemporal dynamics in Arabidopsis circadian clock 10:55 - Deciphering the role of rhythmic stability for circadian dynamics through single-cell analysis and mathematical modeling 11:20 - Fundamental limits to (Deep) Learning circadian clock phase from single-cell snapshot data 11:45 - Modelling Entrainment in Arabidopsis 12:00 - WANTED: Nonlinearities & Long Delays 12:15 - PyCycleBio: modelling non-sinusoidal-oscillator systems in circadian biology

Symposium 23: CIRCADIAN REGULATION OF IMMUNITY

10:30 – 12:30 (AM 1)
10:30 - Host immune responses and circadian rhythms in the context of malaria and leishmaniasis 10:55 - The molecular circadian clock in asthma 11:20 - Exploring the role of circadian rhythms in Neurodevelopmental disorders 11:45 - Time-restricted feeding provides limited microglial immunometabolic improvements in diet-induced obese rats 12:00 - Uncovering the circadian basis of vascular homeostasis 12:15 - Chronic inflammatory arthritis alters the circadian rhythms of liver macrophages

Symposium 24: AT THE INTERSECTION OF LIGHT, SLEEP, AND CIRCADIAN TIMING (ACS-EBRS JOINT SYMPOSIUM)

10:30 – 12:30 (AM 3)
10:30 - Interactive effects of sleep, circadian timing, and light on mood and cognition in adolescents 10:55 - Individual variability in light-dark patterns and circadian entrainment 11:20 - New perspectives on the molecular control of circadian timing and sleep 11:45 - Ultradian cycles within sleep: how are they shaped by circadian and sleep homeostatic processes? 12:00 - Misalignment of peripheral circadian rhythms is associated with irregular sleep 12:15 - Mapping the conflict between social time and sun time: sleep patterns from a large wearable data donation project confirm spatiotemporal solar influences year-round

Symposium 25: SEASONALITY

10:30 – 12:30 (AM 2)
10:30 - Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity 10:55 - Photoperiodism and temperature interaction in voles 11:20 - The winter blue-greens: how cyanobacteria anticipate the seasons 11:45 - Longitudinal variation in sleep and circadian rhythms across season and photoperiod: Results from the Ecology of Human Sleep (EcoSleep) Cohort Study 12:00 - How daily and seasonal timing aids polar adaptation in Antarctic krill (Euphausia superba) 12:15 - Seasonal signaling between the pars tuberalis and tanycytes: a comparative study between a mammal and bird
12:30 – 14:00 - Lunch Break and Poster Session C

14:00 – 14:30 - Awards